Creating this incredible Amish Hamburger Steak Bake can be straightforward if you follow these simple steps:

1. Preheat Oven: Preheat your oven to 375°F (190°C).
2. Cook the Beef: In a large skillet over medium heat, brown the ground beef. Drain excess fat.
3. Add Aromatics: Add the chopped onion and minced garlic to the skillet. Cook until the onion is translucent.
4. Incorporate Mushrooms: Stir in the sliced mushrooms and cook for another 3-4 minutes until tender.
5. Mix Vegetables: Add the frozen mixed vegetables, cream of mushroom soup, milk, Worcestershire sauce, salt, pepper, garlic powder, and onion powder. Stir until well combined.
6. Transfer to Baking Dish: Pour the beef mixture into a greased 9×13-inch baking dish, spreading it out evenly.
7. Add Cheese: Sprinkle the shredded cheddar cheese over the beef mixture.
8. Prepare Biscuit Topping: Open the package of refrigerated biscuit dough and cut each biscuit into quarters. Distribute the biscuit pieces evenly over the cheese layer.
9. Bake: Place the baking dish in the preheated oven and bake for 30-35 minutes or until the biscuits are golden brown and cooked through.
10. Cool: Remove from the oven and let it cool for about 5 minutes before serving.

These steps will guide you in creating this delicious dish effortlessly.